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I only got my sheepdog a rabies vaccination one time and she had a bad reaction (her fur got darker at the injection site and she developed skin problems; I don't know if it was directly caused by the vaccine but I wasn't going to take any chances) so I never got her another one
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My mothers dog is extremely allergic to pretty much everything, including vaccines. He collapsed in anaphylactic shock 3 minutes after getting his shots. She was given an exemption from the state's rabies license requirements.